Cilofexor mol hemisulfate 71 L/kg) and a low

71 L/kg) and a low systemic clearance (31

is a potent monoamine transporter inhibitor

and TNF-α is introduced as a positive control for NF-κB activation

Epub 2018 Nov 13

Cilofexor mol hemisulfate 71 L/kg) and a lowCilofexor (GS 9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. Cilofexor has anti inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research. Product information CAS Number: 1418274 28 8 Molecular Weight: 586. 85 Formula: C28H22Cl3N3O5 Chemical Name: 2 [3 (2 chloro 4 {[5 cyclopropyl 3 (2,6 dichlorophenyl) 1,2